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代謝 微生物学・ウィルス学 神経科学 NF-Κb 酸化還元 PI3K/Akt/mTORシグナル プロテアーゼ・プロテアソーム
幹細胞 チロシンキナーゼ・アダプター ユビキチン その他 PROTAC
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Search Results for " Retinoic acid receptors "

ターゲット

Retinoid Receptor

31

阻害剤

5

天然化合物

3

リコンビナントタンパク質

カタログ番号 製品名 別名 ターゲット
T3955 AR7 Retinoid Receptor
AR7 is a retinoic acid receptor α (RARα) antagonist.
T22843 HX 531 Retinoid Receptor
RXR antagonist
T17209 UVI 3003 Retinoid Receptor , Autophagy
UVI 3003 is a highly selective antagonist of the retinoid X receptor. UVI 3003 inhibits Xenopus and human RXRα in Cos7 cells (IC50s: 0.22 and 0.24 μM, respectively).
TQ0097 AGN 193109 Retinoid Receptor , Autophagy
AGN 193109, a retinoid analog, is a potent and specific antagonist of RARs (Kds: 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ).
T5341 WYC-209 WYC209 Apoptosis , Retinoid Receptor , Autophagy
WYC-209 inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs, IC50: 0.19 uM). It targets the retinoic acid receptor (RAR).
T7370 Talarozole R115866 Others , P450 , Retinoid Receptor , Autophagy
Talarozole (R115866) is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.46 nM, respectively.Talarozole for the treatment of...
T7586 Trifarotene CD5789 Retinoid Receptor , Autophagy
Trifarotene (CD5789) is a potent and selective RARγ agonist with 65-fold and 16-fold selectivitiy for the RARγ (EC50=7.7 nM) over RARα (EC50=500 nM) and RARβ (EC50=125 nM).
TQ0064 Peretinoin NIK333 HCV Protease , Retinoid Receptor , S1P Receptor , Autophagy
Peretinoin (NIK333) is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR.
T23383 SR11237 SR 11237 Others , RAR/RXR 
SR11237 is a Pan retinoid X receptor (RXR) agonist. SR11237 causes RXR/RXR homodimers to form and transactivate a reporter gene containing a RXR-response element.
T6696 Tazarotene Tazorac,AGN 190168,Zorac Retinoid Receptor , Autophagy
Tazarotene (Zorac) is a synthetic, topical retinoid. Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. In psoriasis, tazarotene normalizes abnormal keratinocyte differentiati...
T1093 Adapalene CD271 Apoptosis , Retinoid Receptor , Autophagy
Adapalene (CD271) is a dual RAR and RXR agonist, utilized in the treatment of skin conditions.
T11844 LG-100064 Retinoid Receptor , Autophagy
LG-100064 is an agonist of retinoid-X-receptor (RXR)(EC50s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ)
T4538 Palovarotene Ro 3300074,R 667 Retinoid Receptor , Autophagy
Palovarotene (Ro 3300074) is an agonist of nuclear retinoic acid receptor γ (RAR-γ).
T21314 Amsilarotene TAC-101,TAC 101,TAC101 CDK
Amsilarotene (TAC101) inhibits the phosphorylation of retinoblastoma gene product (RB) and increases the presence of 2 cyclin-dependent kinases (CDK) inhibitors resulting in cell cycle arrest. This agent also causes a cy...
T6694 Tamibarotene NSC 608000,Am 80,Amnolake Apoptosis , Retinoid Receptor , Autophagy
Tamibarotene (Amnolake) is an orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, with potential antineoplastic activity.
T1872 Fenretinide 4-HPR,MK-4016,4-hydroxy(phenyl)retinamide Retinoid Receptor , Autophagy
Fenretinide (4-HPR) is an orally-active synthetic retinoid derivative with potential antineoplastic and chemopreventive activities.
T21714 BMS453 BMS 453,BMS-189453 Retinoid Receptor
BMS453 (BMS-189453), a synthetic retinoid, is a potent and selective agonist of RARβ and a potent testicular toxin. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ.
T5843 Tarenflurbil MPC7869,(R)-Flurbiprofen,R-flurbiprofen Retinoid Receptor , Autophagy
Tarenflurbil ((R)-Flurbiprofen) is the non-cyclooxygenase inhibiting R-enantiomer of the non-steroidal anti-inflammatory drug flurbiprofen, which was assessed as a remedy for Alzheimer's disease.
T1288 TTNPB AGN191183,Arotinoid acid,Ro 13-7410,AGN-191183,Ro 13-7410 Apoptosis , Retinoid Receptor , Autophagy
TTNPB (Ro 13-7410,AGN-191183), a potent RAR agonist, inhibits binding of [3H]tRA of human RARα (IC50: 5.1 nM), β (IC50: 4.5 nM), and γ (IC50: 9.3 nM), respectively.
T11847L Liarozole R75251 dihydrochloride P450 , Retinoid Receptor
Liarozole (R75251 dihydrochloride) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 1...
T5854 AM580 NSC608001,CD336,Ro 40-6055 Retinoid Receptor , Autophagy
AM580 (CD336) is a retinoic acid receptor agonist that is selective for RARα( IC50 : 8 nM )
T6410 Bexarotene Ro 26-4455,Targretin,LGD1069 Retinoid Receptor , Autophagy
Bexarotene (LGD1069) is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL).
T4371 CD437 AHPN,O-Desmethyl Adapalene,Apoptosis Activator VI Retinoid Receptor , Autophagy
CD437 (AHPN) is a specifc Retinoic Acid Receptor γ (RARγ) agonist.
T0499 Oxybenzone KAHSCREEN BZ-3,Benzophenone 3,Eusolex 4360,Escalol 567 Apoptosis , Retinoid Receptor , Autophagy
Oxybenzone (Eusolex 4360) is an organic compound used in sunscreens. It is a derivative of benzophenone.
T15811 LY2955303 Others , Retinoid Receptor
LY2955303 is an effective and selective retinoic acid receptor gamma (RARγ) antagonist (Ki: 1.09 nM).
T12516 Polyinosinic-polycytidylic acid sodium Poly(I:C) sodium Apoptosis , Others , TLR
Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MD...
T68104 Mofarotene Ro-40-8757,Ro 40-8757 Retinoid Receptor
Mofarotene (Ro-40-8757) is a small molecule compound that shows considerable antitumor activity in many cancer cell lines and can be used for the treatment of tumors and respiratory diseases.Mofarotene is a retinoic acid...
T37414 CAY10771
CAY10771 is a dual agonist of farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor δ (PPARδ).1It activates FXR and PPARδ in reporter assays using HEK293T cells (EC50s = 0.94 and 1.5 μM, respectively)...
T71933 GNE-3500
GNE-3500 is a Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C (RORc or RORγ) Inverse Agonist. Retinoic acid receptor-related orphan receptor C (RORc, RORγ, or NR1F3) is a nucle...
T36998 7β,27-dihydroxy Cholesterol 7β,27-DHC,7β,27-dihydroxy Cholesterol
7β,27-dihydroxy Cholesterol is an oxysterol and agonist of retinoic acid receptor-related orphan receptor γ (RORγ) and RORγt. [1] It activates RORγ- or RORγt-dependent signaling with EC50 values of 691 and 1,045 nM, res...
T74052 Polyinosinic-polycytidylic acid potassium
Polyinosinic-polycytidylic acid potassium (Poly(I:C) potassium), a synthetic double-stranded RNA analog, serves as an agonist for toll-like receptor 3 (TLR3) and retinoic acid-inducible gene I (RIG-I)-like receptors (RIG...

Compounds

AR7
T3955
Synonym:
Target: Retinoid Receptor
HX 531
T22843
Synonym:
Target: Retinoid Receptor
UVI 3003
T17209
Synonym:
Target: Retinoid Receptor, Autophagy
AGN 193109
TQ0097
Synonym:
Target: Retinoid Receptor, Autophagy
WYC-209
T5341
Synonym: WYC209
Target: Apoptosis, Retinoid Receptor, Autophagy
Talarozole
T7370
Synonym: R115866
Target: Others, P450, Retinoid Receptor, Autophagy
trifarotene
T7586
Synonym: CD5789
Target: Retinoid Receptor, Autophagy
Peretinoin
TQ0064
Synonym: NIK333
Target: HCV Protease, Retinoid Receptor, S1P Receptor, Autophagy
SR11237
T23383
Synonym: SR 11237
Target: Others, RAR/RXR 
Tazarotene
T6696
Synonym: Tazorac,AGN 190168,Zorac
Target: Retinoid Receptor, Autophagy
Adapalene
T1093
Synonym: CD271
Target: Apoptosis, Retinoid Receptor, Autophagy
LG-100064
T11844
Synonym:
Target: Retinoid Receptor, Autophagy
palovarotene
T4538
Synonym: Ro 3300074,R 667
Target: Retinoid Receptor, Autophagy
Amsilarotene
T21314
Synonym: TAC-101,TAC 101,TAC101
Target: CDK
Tamibarotene
T6694
Synonym: NSC 608000,Am 80,Amnolake
Target: Apoptosis, Retinoid Receptor, Autophagy
Fenretinide
T1872
Synonym: 4-HPR,MK-4016,4-hydroxy(phenyl)retinamide
Target: Retinoid Receptor, Autophagy
BMS453
T21714
Synonym: BMS 453,BMS-189453
Target: Retinoid Receptor
Tarenflurbil
T5843
Synonym: MPC7869,(R)-Flurbiprofen,R-flurbiprofen
Target: Retinoid Receptor, Autophagy
TTNPB
T1288
Synonym: AGN191183,Arotinoid acid,Ro 13-7410,AGN-191183,Ro 13-7410
Target: Apoptosis, Retinoid Receptor, Autophagy
Liarozole
T11847L
Synonym: R75251 dihydrochloride
Target: P450, Retinoid Receptor
AM580
T5854
Synonym: NSC608001,CD336,Ro 40-6055
Target: Retinoid Receptor, Autophagy
Bexarotene
T6410
Synonym: Ro 26-4455,Targretin,LGD1069
Target: Retinoid Receptor, Autophagy
CD437
T4371
Synonym: AHPN,O-Desmethyl Adapalene,Apoptosis Activator VI
Target: Retinoid Receptor, Autophagy
Oxybenzone
T0499
Synonym: KAHSCREEN BZ-3,Benzophenone 3,Eusolex 4360,Escalol 567
Target: Apoptosis, Retinoid Receptor, Autophagy
LY2955303
T15811
Synonym:
Target: Others, Retinoid Receptor
Polyinosinic-polycytidylic acid sodium
T12516
Synonym: Poly(I:C) sodium
Target: Apoptosis, Others, TLR
Mofarotene
T68104
Synonym: Ro-40-8757,Ro 40-8757
Target: Retinoid Receptor
CAY10771
T37414
Synonym:
Target:
GNE-3500
T71933
Synonym:
Target:
7β,27-dihydroxy Cholesterol
T36998
Synonym: 7β,27-DHC,7β,27-dihydroxy Cholesterol
Target:
Polyinosinic-polycytidylic acid potassium
T74052
Synonym:
Target:
カタログ番号 製品名 別名 ターゲット
T1051 Retinoic acid Vitamin A acid,ATRA,all-trans-Retinoic acid,Tretinoin Retinoid Receptor , Endogenous Metabolite , PPAR , Autophagy
Retinoic acid (Tretinoin), a metabolite of vitamin A, is a natural agonist of the retinoic acid receptor RAR and inhibits RARα/β/γ (IC50=14 nM). Retinoic acid induces cellular differentiation, reduces cellular proliferat...
T1611 Isotretinoin 13-cis-Retinoic acid Retinoid Receptor , Endogenous Metabolite , Autophagy
Isotretinoin (13-cis-Retinoic acid) binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. Isotretinoin is a naturall...
TN6735 Bigelovin Apoptosis , Reactive Oxygen Species , Retinoid Receptor , Autophagy , RAR/RXR 
Bigelovin is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation.It is also known as a pote...
T1330 Acitretin Ro 10-1670,Etretin Apoptosis , Retinoid Receptor , Autophagy
Acitretin (Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis.
T3000 Magnolol NSC 293099,5,5'-Diallyl-2,2'-biphenyldiol NF-κB , Retinoid Receptor , Antibacterial , PPAR , p53 , Autophagy
Magnolol (5,5'-Diallyl-2,2'-biphenyldiol) is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.

天然物製品

Retinoic acid
T1051
Synonym: Vitamin A acid,ATRA,all-trans-Retinoic acid,Tretinoin
Target: Retinoid Receptor, Endogenous Metabolite, PPAR, Autophagy
Isotretinoin
T1611
Synonym: 13-cis-Retinoic acid
Target: Retinoid Receptor, Endogenous Metabolite, Autophagy
Bigelovin
TN6735
Synonym:
Target: Apoptosis, Reactive Oxygen Species, Retinoid Receptor, Autophagy, RAR/RXR 
Acitretin
T1330
Synonym: Ro 10-1670,Etretin
Target: Apoptosis, Retinoid Receptor, Autophagy
Magnolol
T3000
Synonym: NSC 293099,5,5'-Diallyl-2,2'-biphenyldiol
Target: NF-κB, Retinoid Receptor, Antibacterial, PPAR, p53, Autophagy

Recombinant Proteins

Species：
Human (3)
Expression System：
E. coli (3)
Tag：
N-6xHis (1)
N-6xHis-SUMO (1)
N-GST (1)
カタログ番号 製品名 Species Expression System
TMPH-02221 TRIM24 Protein, Human, Recombinant (His & SUMO) Human E. coli
Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the high...
TMPH-01650 PRAME Protein, Human, Recombinant (E. coli, His) Human E. coli
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation. The CRL2(PRAME) complex mediates ubiquitination a...
TMPJ-01213 ASXL1 Protein, Human, Recombinant (GST) Human E. coli
Putative Polycomb group protein ASXL1 involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma...
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